A study was done with six people to compare the effects of three different forms of vitamin B12 - a standard capsule/tablet, liquid traditional liposome and a CELLg8 liposomal. Each person was given 3 mg of vitamin B12 in one form, waited 14 days for a wash out period, and then took the other form (N=18). CELLg8 outperformed standard delivery abs traditional liposomal delivery. The average increase was six times more after taking CELLg8.

The efficacy of higher doses (0.5 mg and 1 mg) of Liposomal Curcumin was found to be better than the 0.25 mg dose in improving metabolic function in subjects with metabolic slowdown. The study followed strict protocols and considered subjects individually to ensure clinical translational efficacy. The results suggest that Liposomal Curcumin can effectively rebound metabolic function.

A study was done with 26 people to compare the effectiveness of a green tea extract found in CELLg8® Green Tea compared to a regular green tea extract found in other supplements. The study was not randomized and the participants didn't know which extract they were taking. They took 200mg of a regular green tea extract twice a day, then had a 14-day break, and then took 200mg of the CELLg8® extract twice a day. Blood samples were taken 24 hours after each consumption to measure the amount of catechin, an important component of green tea, in their blood.

A study was done with 25 healthy people who took either a multivitamin/mineral supplement in a special form called liposomal or a regular multivitamin/mineral supplement. Their blood was tested for iron and magnesium levels at the start and every two hours for six hours. The results showed that iron levels were higher in people who took the liposomal supplement compared to the regular one. However, magnesium levels were not different between the two groups. The researchers found that the special liposomal form helped the body absorb iron better.

In a study, participants took a one-time 5-gram dose of a liposomal ketone product. Blood ketones were measured before and after taking the product, and the results showed a significant increase in blood ketones starting 15 minutes after ingestion. The highest increase was seen at 30 minutes, with an average level of 214% over the baseline. The blood ketones stayed above the baseline level for over two hours. The study suggests that liposomal ketones are quickly absorbed into the bloodstream and provide the benefits of a ketogenic diet without dietary restrictions.

The results of this study of postmenopausal women indicate that CELLg8® SLEEP significantly improves sleep duration and decreases the number of awakenings, compared to placebo. While the results of the sleep duration were varied, the majority of subjects reported a decrease in the number of times awakened during the night. The study also suggests that chronic pain may have affected the results of the study. Additionally, 75% of the subjects preferred the SLEEP product over the placebo.

15 healthy people were tested for their Vitamin D levels, then took a liposomal product with 125 mcg Vitamin D and 400 mcg Vitamin K for 30 days. On average, their Vitamin D levels increased by 73%, compared to a 16% average increase from non-liposomal Vitamin D supplementation. The increase was even greater for those who started with low Vitamin D levels, with an average increase of 112% in the liposomal vitamin D group.

The study shows that taking liposomal Vitamin D leads to better Vitamin D absorption, resulting in higher levels compared to traditional non-liposomal Vitamin D supplementation.

This study examined the impact of multivitamin and mineral (MVM) treatments on calcium levels. Univariate analysis showed no significant changes in calcium levels over time or interactions between treatments. However, the liposomal treatment resulted in a significant increase in calcium levels compared to baseline at 2 hours, with no differences between treatments. Further analysis indicated that calcium levels increased after liposomal ingestion at 2 hours and tended to be significantly greater than non-liposomal values at 2 and 6 hours. Interestingly, although the MVM supplements did not contain calcium, the provision of the liposomal MVM appeared to enhance calcium absorption.

This study investigated the effects of liposomal multivitamin and mineral (MVM) ingestion on vitamin A levels. Univariate analysis showed no significant time or time x treatment interaction effects. However, vitamin A levels significantly increased after 2 hours of liposomal MVM ingestion, with no significant changes observed among treatments. When expressed as percent changes from baseline, the NL treatment group had higher vitamin A levels after 2 hours, while the L treatment showed a progressive increase over time, peaking at 6 hours. PK analysis revealed significant treatment effects, with the volume of distribution steady-state (Vss) area tending to be lower and systemic clearance tending to be higher with liposomal MVM ingestion.

This study investigated the effects of liposomal multivitamin and mineral (MVM) ingestion on vitamin E levels. Univariate analysis revealed a significant increase in vitamin E levels after 2 hours of liposomal MVM ingestion, with no significant changes observed among standard treatments. When expressed as percent changes from baseline, the non-liposomal treatment group had much lower vitamin E levels after 4 hours, while the liposomal treatment showed a progressive increase over time, peaking at 6 hours.

This study investigated the impact of ingesting a liposomal multivitamin and mineral (MVM) supplement compared to a non-liposomal MVM supplement on the appearance and clearance of vitamins and minerals in the bloodstream. In a double-blind, randomized, and counterbalanced trial, 34 healthy individuals fasted for 12 hours and consumed either the non-liposomal (NL) or liposomal (L) MVM supplement along with a standardized snack. Blood samples were taken at 0, 2, 4, and 6 hours after ingestion and analyzed for a range of vitamins and minerals. Statistical analyses revealed significant interactions between treatment and time for the evaluated vitamins and minerals, indicating differential effects between the two supplements. Various parameters such as volume distribution, median residence time, clearance rates, elimination half-life, and distribution/absorption phase were also affected differently by the two treatments for different vitamins and minerals. Specifically, liposomal MVM ingestion resulted in lower volume distribution of vitamins compared to non-liposomal MVM sources, suggesting improved clearance and absorption despite similar nutrient intake. These findings demonstrate that coating an MVM supplement with liposomes alters the pharmacokinetic profiles of individual nutrients. Liposomal formulations have proven to be significantly more effective with the same dosage.

The ingestion of a liposomal multivitamin and mineral (MVM) supplement has distinct effects on the concentrations of certain vitamins and minerals in the bloodstream, their distribution throughout the body, clearance rates, and removal from the blood when compared to a non-liposomal MVM supplement. These findings are significant because they are the first to show that encapsulating an MVM supplement with liposomes can influence the pharmacokinetic (PK) profile of multiple vitamins and minerals present in the supplement, thereby impacting the availability of nutrients. Further research could establish this as a more efficient method of delivering vitamins and minerals in dietary supplements. However, more studies are necessary to determine how coating an MVM supplement with liposomes affects tissue absorption, metabolic function, and overall health. The current findings support the notion that enveloping an MVM supplement with liposomes influences the bioavailability of individual nutrients contained within the supplement.